Marimuthu, M. and Praveen Kumar, B. and Mariya Salomi, L. and Veerapandian, M. and Balamurugan, K. (2018) Methylene Blue-Fortified Molybdenum Trioxide Nanoparticles: Harnessing Radical Scavenging Property. ACS Applied Materials & Interfaces, 10 (50). pp. 43429-43438. ISSN 1944-8244

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A hybrid nanosystem with impeccable cellular imaging and antioxidant functionality is demonstrated. The microwave irradiation-derived molybdenum trioxide nanoparticles (MoO3 NPs) were surface-functionalized with the cationic dye molecule, methylene blue (MB), which enables superior UV−visible absorbance and fluorescence emission wavelengths potential for bioimaging. The radical scavenging property of the pristine MoO3 NPs and MoO3−MB NPs were studied in vivo using Caenorhabditis elegans as the model system. Heat shock-induced oxidative stress in C. elegans was significantly resolved by the MoO3−MB NPs, in agreement with the in vitro radical scavenging study by electron paramagnetic resonance spectroscopy. Hybrid nanostructures of MoO3−MB demonstrate synergistic benefits in intracellular imaging with intrinsic biocompatibility and antioxidant behavior, which can facilitate application as advanced healthcare materials toward bioimaging and clinical therapeutics.

Item Type: Article
Uncontrolled Keywords: Caenorhabditis elegans; cellular imaging; dye-modified metal oxide; methylene blue; molybdenum trioxide; radical scavenger
Subjects: Functional Materials
Depositing User: Dr Murugan Veerapandian
Date Deposited: 03 May 2019 11:44
Last Modified: 03 May 2019 11:44

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